Identification of functional sites
From Proteinfunction.net
As the number of protein sequences with unknown function increases, assigning accurate function to unknown protein becomes increasingly an important issue. Protein structure can provide an important clue for function prediction, but the relationship between structure and function is complex. Accordingly, the necessity to overcome this complexity has been increased. Recently, there have been many attempts to predict function using functional local sites in protein structure. In protein, especially enzyme, function is typically encoded in a small number of residues located in the active site, which are dispersed along the protein sequence but packed in binding pocket. Many methods have been designed that use a certain local site as a functional mark, in particular, ligand binding site that would be one of the specific region which function encoded.
- Scheme: Comparison of binding pocket and find similar local structures
- Various algorithms to compare local structures
