Function Annotation schemes
From Proteinfunction.net
EC
The EC number defines function of protein according to its catalytic reaction. Each EC number consists of 4 digits ( e.g. 1.4.5.12), each represent different level functional categories. Top level( first digit) number is 1 to 6 and they represent Oxidoreductases, Transferases, Hydrolase, Lyases, Isomerases, Ligases. Remaining sub-digits represents sub-functional category from the top level catalytic types.
This database contains the known enzyme structures that have been deposited in the Protein Data Bank (PDB). There are currently 20,695 PDB-enzyme entries in the PDB (as at 10 February, 2007) involving 18,525 separate PDB files - some files having more than one E.C. number associated with them
Reference
- http://www.chem.qmul.ac.uk/iubmb/enzyme/
- http://www.expasy.org/enzyme/
- http://www.ebi.ac.uk/thornton-srv/databases/enzymes/
GO
This logical structure of a functional classification has been constructed by the Gene Ontology Consortium (2000).
The gene ontology is divided into three categories :
- Molecular function : a function that an individual protein or RNA molecule does. This is a function from the biochemists' point of view.
- Biological process : a component of the activities of a living system, mediated by a protein or RNA, such as signal transduction or cyclic AMP synthesis. This is a function from the cell's point of view.
- Cellular component : the assignment of site of activity or partners such as nucleus or ribosome.
